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The first trailer for the highly anticipated dramedy Life Itself has been released!

The movie – starring Olivia Wilde, Oscar Isaac, Annette Bening, and Antonio Banderas – weaves together the stories of multiple characters who interact with one another stretching from New York to the Spanish countryside.

PHOTOS: Check out the latest pics of Olivia Wilde

The movie was written and directed by This Is Us creator Dan Fogelman and will be released through Amazon Studios.

Life Itself hits theaters on September 21.

Watch the trailer!

Life Itself Trailer

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